Incorporating spatial-anatomical similarity into the VGWAS framework for AD biomarker detection.
Huang M, Yu Y, Yang W et al.
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Motivation: The detection of potential biomarkers of Alzheimer's disease (AD) is crucial for its early prediction, diagnosis and treatment. Voxel-wise genome-wide association study (VGWAS) is a commonly used method in imaging genomics and usually applied to detect AD biomarkers in imaging and genetic data. However, existing VGWAS methods entail large computational cost and disregard spatial correlations within imaging data. A novel method is proposed to solve these issues.
708 European ancestry individuals
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