Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study.
Emdin CA, Haas M, Ajmera V et al.
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Background & aims: In contrast to most other common diseases, few genetic variants have been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that predispose to cirrhosis, to test whether such variants, aggregated into a polygenic score, enable genomic risk stratification, and to test whether alcohol intake or body mass index interacts with polygenic predisposition.
4,829 European, African, Asian and unknown ancestry cases, 72,705 European, African, Asian and unknown ancestry controls, 362,539 European, African, Asian and unknown ancestry individuals with ALT measurements
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