Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study.
Machipisa T, Chong M, Muhamed B et al.
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Importance: Rheumatic heart disease (RHD), a sequela of rheumatic fever characterized by permanent heart valve damage, is the leading cause of cardiac surgery in Africa. However, its pathophysiologic characteristics and genetics are poorly understood. Understanding genetic susceptibility may aid in prevention, control, and interventions to eliminate RHD.
601 European ancestry, South East Asian ancestry, South Asian ancestry, African ancestry and South African ancestry cases, 454 European ancestry, South East Asian ancestry, South Asian ancestry, African ancestry and South African ancestry controls
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