Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project.
Hu Y, Haessler JW, Manansala R et al.
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Background and purpose: Stroke is the leading cause of death and long-term disability worldwide. Previous genome-wide association studies identified 51 loci associated with stroke (mostly ischemic) and its subtypes among predominantly European populations. Using whole-genome sequencing in ancestrally diverse populations from the Trans-Omics for Precision Medicine (TOPMed) Program, we aimed to identify novel variants, especially low-frequency or ancestry-specific variants, associated with all stroke, ischemic stroke and its subtypes (large artery, cardioembolic, and small vessel), and hemorrhagic stroke and its subtypes (intracerebral and subarachnoid).
296 European ancestry cases, 17,021 European ancestry controls, 33 African American or Afro-Caribbean cases, 6,855 African American or Afro-Caribbean controls, 19 Hispanic or Latin American cases, 2,256 Hispanic or Latin American controls, 4 Asian ancestry cases, 734 Asian ancestry controls, 34 Native American ancestry individuals, 216 controls
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