Does Thrombosis Play a Causal Role in Lacunar Stroke and Cerebral Small Vessel Disease?
Koohi F, Harshfield EL, Shatunov A et al.
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The importance of thromboembolism in the pathogenesis of lacunar stroke (LS), resulting from cerebral small vessel disease (cSVD), is debated, and although antiplatelets are widely used in secondary prevention after LS, there is limited trial evidence from well-subtyped patients to support this approach. We sought to evaluate whether altered anticoagulation plays a causal role in LS and cSVD using 2-sample Mendelian randomization.
37,355 European ancestry individuals
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