Genetic variants associated with mandibular osteoradionecrosis following radiotherapy for head and neck malignancy.
Brooker RC, Antczak P, Liloglou T et al.
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Abstract
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Background/aim: Utilising radiotherapy in the management of head and neck cancer (HNC) often results in long term toxicities. Mandibular osteoradionecrosis (ORN) represents a late toxicity associated with significant morbidity. We aim to identify a panel of common genetic variants which can predict ORN to aid development of personalised radiotherapy protocols.
52 cases, 89 controls
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