Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Kanoni S, Graham SE, Wang Y et al.
Publication Details
Comprehensive information about this research publication
Authors
Abstract
Summary of the research findings
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.
1,238,180 European, East Asian, Hispanic, admixed African or South Asian ancestry individuals
Study Statistics
Key metrics and study information
Analysis
Comprehensive review of health and genetic findings
Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.
Analysis In Progress
Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.
Summary
Key Findings
Health Insights
Disease Analysis
Genetic Trait Analysis
Clinical Relevance
Scientific Assessment
Related Publications
Other publications that may be of interest
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
Rajabli F
Genome Biol
Alzheimer's disease
Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study.
Hu Y
PLoS Genet
High density lipoprotein cholesterol levels
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
McCartney DL
Genome Biol
DNA methylation-estimated granulocyte proportions
Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population.
Hebbar P
J Lipid Res
High density lipoprotein cholesterol levels
Heritability and genetic associations of triglyceride and HDL-C levels using pedigree-based and empirical kinships.
Blackburn NB
BMC Proc
High density lipoprotein cholesterol levels
Explore More Research
Discover the latest findings in health and genetic research