Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation and immune response.
Carreras-Torres R, Kim AE, Lin Y et al.
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Abstract
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Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer.
18,781 European ancestry ever-smoker cases, 14,975 European ancestry never-smoker cases, 22,370 European ancestry ever-smoker controls, 21,976 European ancestry never-smoker controls
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