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Identifying Genetic Loci and Phenomic Associations of Substance Use Traits: A Multi-trait Analysis of GWAS (MTAG) study.

Xu H, Toikumo S, Crist RC et al.

37156939 PubMed ID
GWAS Study Type
74635 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

XH
Xu H
TS
Toikumo S
CR
Crist RC
GK
Glogowska K
JZ
Jinwala Z
DJ
Deak JD
JA
Justice AC
GJ
Gelernter J
JE
Johnson EC
KH
Kranzler HR
KR
Kember RL
Chapter II

Abstract

Summary of the research findings

Background and aims: Genome-wide association studies (GWAS) of opioid use disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use disorder (AUD) and smoking, where many more loci have been identified. We sought to identify novel loci for substance use traits (SUTs) in both African- (AFR) and European- (EUR) ancestry individuals to enhance our understanding of the traits' genetic architecture.

74,635 European ancestry individuals (MTAG effective sample size boosted by cannabis use disorder, alcohol use disorder, smoking samples)

Chapter III

Study Statistics

Key metrics and study information

74635
Total Participants
GWAS
Study Type
No
Replicated
European, African unspecified
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

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