Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.
Chebii VJ, Wade AN, Crowther NJ et al.
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Abstract
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Aims/hypothesis: Glycaemic traits such as high fasting glucose levels and insulin resistance are positively associated with the risk of type 2 diabetes and other cardiometabolic diseases. Genetic association studies have identified hundreds of associations for each glycaemic trait, yet very few studies have involved continental African populations. We report the results of genome-wide association studies (GWASs) in a pan-African cohort for four glycaemic traits, namely fasting glucose, fasting insulin, insulin resistance (HOMA-IR) and beta cell function (HOMA-B), which are quantitative variables that affect the risk of developing type 2 diabetes.
9,989 Sub-Saharan African ancestry individuals
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