Genetic associations between Serotonin Receptor 1F (<i>HTR1F</i>) regulatory variation and sleep apnea in non-obese individuals: Insights from GWAS and eQTL analyses.
Strausz S, Broberg M, Jones SE et al.
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Sleep apnoea is a common sleep disorder affecting at least 10% of the population. It is caused by lack of breathing during sleep, typically mediated by obstruction of airways or less frequently by misdirected central signals for breathing. The primary risk factor is a high body mass index, causing airway obstruction. However, understanding risk factors for sleep apnoea in non-obese (body mass index <30 kg·m-2) individuals requires further exploration. Our goal was to elucidate genetic risk factors for sleep apnoea in non-obese individuals.
20,413 Finnish ancestry cases, 443,463 Finnish ancestry controls
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