Genomics of chronic dry cough unravels neurological pathways.
Coley K, John C, Ghouse J et al.
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Abstract
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Chronic dry cough is a symptom of common lung conditions, can occur as a side-effect of angiotensin-converting enzyme inhibitors (ACEis), or may be unexplained. Despite the substantial health burden presented by chronic dry cough, its biological mechanisms remain unclear. We hypothesised shared genetic architecture between chronic dry cough and ACEi-induced cough and aimed to identify causal genes underlying both phenotypes.
226 African ancestry cases, 1,061 African ancestry controls, 27,772 European ancestry cases, 141,390 European ancestry controls, 32 East Asian ancestry cases, 116 East Asian ancestry controls, 1,057 South Asian ancestry cases, 8,532 South Asian ancestry controls, 71 cases, 123 controls
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