Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.
Debette S, Bis JC, Fornage M et al.
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Abstract
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Background and purpose: Previous studies examining genetic associations with MRI-defined brain infarct have yielded inconsistent findings. We investigated genetic variation underlying covert MRI infarct in persons without histories of transient ischemic attack or stroke. We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
9,401 European ancestry individuals
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