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GWAS Study

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Cho MH, McDonald ML, Zhou X et al.

24621683 PubMed ID
GWAS Study Type
14988 Participants
388 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CM
Cho MH
MM
McDonald ML
ZX
Zhou X
MM
Mattheisen M
CP
Castaldi PJ
HC
Hersh CP
DD
Demeo DL
SJ
Sylvia JS
ZJ
Ziniti J
LN
Laird NM
LC
Lange C
LA
Litonjua AA
SD
Sparrow D
CR
Casaburi R
BR
Barr RG
RE
Regan EA
MB
Make BJ
HJ
Hokanson JE
LS
Lutz S
DT
Dudenkov TM
FH
Farzadegan H
HJ
Hetmanski JB
TR
Tal-Singer R
LD
Lomas DA
BP
Bakke P
GA
Gulsvik A
CJ
Crapo JD
SE
Silverman EK
BT
Beaty TH
Chapter II

Abstract

Summary of the research findings

The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are still largely unknown. Additional genetic variants are likely to be identified by genome-wide association studies in larger cohorts or specific subgroups. We sought to identify risk loci for moderate to severe and severe COPD with data from several cohort studies.

5,812 European ancestry cases, 3,955 European ancestry controls, 821 African American cases, 1,749 African American controls

Chapter III

Study Statistics

Key metrics and study information

14988
Total Participants
GWAS
Study Type
Yes
Replicated
2,651 cases and their relatives
Replication Participants
African American or Afro-Caribbean, European
Ancestry
U.S., Norway
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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