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GWAS Study

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

Wain LV, Shrine N, Miller S et al.

26423011 PubMed ID
GWAS Study Type
14654 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

WL
Wain LV
SN
Shrine N
MS
Miller S
JV
Jackson VE
NI
Ntalla I
SA
Soler Artigas M
BC
Billington CK
KA
Kheirallah AK
AR
Allen R
CJ
Cook JP
PK
Probert K
OM
Obeidat M
BY
Bossé Y
HK
Hao K
PD
Postma DS
PP
Paré PD
RA
Ramasamy A
MR
Mägi R
ME
Mihailov E
RE
Reinmaa E
ME
Melén E
OJ
O'Connell J
FE
Frangou E
DO
Delaneau O
FC
Freeman C
PD
Petkova D
MM
McCarthy M
SI
Sayers I
DP
Deloukas P
HR
Hubbard R
PI
Pavord I
HA
Hansell AL
TN
Thomson NC
ZE
Zeggini E
MA
Morris AP
MJ
Marchini J
SD
Strachan DP
TM
Tobin MD
HI
Hall IP
Chapter II

Abstract

Summary of the research findings

Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). We used UK Biobank data to study the genetic causes of smoking behaviour and lung health.

9,748 European ancestry individuals with low FEV1 measurements, 4,906 European ancestry individuals with high FEV1 measurements

Chapter III

Study Statistics

Key metrics and study information

14654
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
U.K.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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