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GWAS Study

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

Hawcutt DB, Francis B, Carr DF et al.

29551627 PubMed ID
GWAS Study Type
488 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HD
Hawcutt DB
FB
Francis B
CD
Carr DF
JA
Jorgensen AL
YP
Yin P
WN
Wallin N
ON
O'Hara N
ZE
Zhang EJ
BK
Bloch KM
GA
Ganguli A
TB
Thompson B
ML
McEvoy L
PM
Peak M
CA
Crawford AA
WB
Walker BR
BJ
Blair JC
CJ
Couriel J
SR
Smyth RL
PM
Pirmohamed M
Chapter II

Abstract

Summary of the research findings

A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify genetic variants affecting susceptibility to corticosteroid-induced adrenal suppression.

up to 35 European ancestry child cases with asthma, at least 372 European ancestry child controls with asthma, general adult population controls

Chapter III

Study Statistics

Key metrics and study information

488
Total Participants
GWAS
Study Type
Yes
Replicated
6 child cases with asthma, 75 child controls with asthma
Replication Participants
European
Ancestry
U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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