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GWAS Study

Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study.

Guillen-Guio B, Lorenzo-Salazar JM, Ma SF et al.

31982041 PubMed ID
GWAS Study Type
1935 Participants
116 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

GB
Guillen-Guio B
LJ
Lorenzo-Salazar JM
MS
Ma SF
HP
Hou PC
HT
Hernandez-Beeftink T
CA
Corrales A
GM
García-Laorden MI
JJ
Jou J
EE
Espinosa E
MA
Muriel A
DD
Domínguez D
LL
Lorente L
MM
Martín MM
RC
Rodríguez-Gallego C
SJ
Solé-Violán J
AA
Ambrós A
CD
Carriedo D
BJ
Blanco J
AJ
Añón JM
RJ
Reilly JP
JT
Jones TK
IC
Ittner CA
FR
Feng R
SF
Schöneweck F
KM
Kiehntopf M
NI
Noth I
SM
Scholz M
BF
Brunkhorst FM
SA
Scherag A
MN
Meyer NJ
VJ
Villar J
FC
Flores C
Chapter II

Abstract

Summary of the research findings

Acute respiratory distress syndrome (ARDS) is a lung inflammatory process caused mainly by sepsis. Most previous studies that identified genetic risks for ARDS focused on candidates with biological relevance. We aimed to identify novel genetic variants associated with ARDS susceptibility and to provide complementary functional evidence of their effect in gene regulation.

274 European ancestry cases, 316 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

1935
Total Participants
GWAS
Study Type
Yes
Replicated
359 European ancestry cases, 986 European ancestry controls
Replication Participants
European
Ancestry
Spain
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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