Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
Armstrong NJ, Mather KA, Sargurupremraj M et al.
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Abstract
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Background and purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first study, to date, we undertook genome-wide association analyses of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings.
16,832 European ancestry individuals, 736 African American individuals, 658 Hispanic individuals
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