Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
Raghavan NS, Dumitrescu L, Mormino E et al.
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Importance: Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase of the disease.
4,120 Europea ancestry individuals, 89 African American individuals, 105 Hispanic individuals
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