Dissecting the genetic heterogeneity of gastric cancer.
Hess T, Maj C, Gehlen J et al.
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Abstract
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Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture.
5,815 European ancestry cases, 10,999 European ancestry controls
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