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Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.

Weiss FU, Schurmann C, Guenther A et al.

25028398 PubMed ID
GWAS Study Type
5410 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

WF
Weiss FU
SC
Schurmann C
GA
Guenther A
EF
Ernst F
TA
Teumer A
MJ
Mayerle J
SP
Simon P
VH
Völzke H
RD
Radke D
GA
Greinacher A
KJ
Kuehn JP
ZM
Zenker M
VU
Völker U
HG
Homuth G
LM
Lerch MM
Chapter II

Abstract

Summary of the research findings

Objective: Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis.

3,966 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

5410
Total Participants
GWAS
Study Type
Yes
Replicated
1,444 European ancestry individuals
Replication Participants
European
Ancestry
Germany
Recruitment Country
Chapter IV

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