52 Genetic Loci Influencing Myocardial Mass.
van der Harst P, van Setten J, Verweij N et al.
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Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death.
59,565 European ancestry individuals, 690 Orcadian (founder/genetic isolate) individuals
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