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GWAS Study

Association of Variants Near the Bradykinin Receptor B<sub>2</sub> Gene With Angioedema in Patients Taking ACE Inhibitors.

Ghouse J, Ahlberg G, Andreasen L et al.

34384552 PubMed ID
GWAS Study Type
55340 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

GJ
Ghouse J
AG
Ahlberg G
AL
Andreasen L
BK
Banasik K
BS
Brunak S
SM
Schwinn M
LI
Larsen IH
PO
Petersen O
SE
Sørensen E
UH
Ullum H
RE
Rasmussen ER
EN
Eriksson N
HP
Hallberg P
WM
Wadelius M
BH
Bundgaard H
OM
Olesen MS
Chapter II

Abstract

Summary of the research findings

Angioedema is a rare but potentially life-threatening adverse reaction associated with angiotensin-converting enzyme (ACE) inhibitors. Identification of potential genetic factors related to this adverse event may help identify at-risk patients.

462 European ancestry ACE inhibitor-associated angioedema cases, 53,391 European ancestry ACE inhibitor-exposed controls

Chapter III

Study Statistics

Key metrics and study information

55340
Total Participants
GWAS
Study Type
Yes
Replicated
142 European ancestry ACE inhibitor-associated angioedema cases, 1,345 European ancestry ACE inhibitor-exposed controls
Replication Participants
European
Ancestry
Denmark, Sweden
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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